Dickkopf-3 function in the prostate
نویسندگان
چکیده
منابع مشابه
Dickkopf-related protein 3 promotes pathogenic stromal remodeling in benign prostatic hyperplasia and prostate cancer
BACKGROUND Compartment-specific epithelial and stromal expression of the secreted glycoprotein Dickkopf-related protein (Dkk)-3 is altered in age-related proliferative disorders of the human prostate. This study aimed to determine the effect of Dkk-3 on prostate stromal remodeling that is stromal proliferation, fibroblast-to-myofibroblast differentiation and expression of angiogenic factors in ...
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Diana Romero, Yoshiaki Kawano*, Nora Bengoa, Marjorie M. Walker, Nicole Maltry, Christof Niehrs, Jonathan Waxman and Robert Kypta Department of Surgery and Cancer, Imperial College London, London, W12 0NN, UK Cell Biology and Stem Cells Unit, CIC bioGUNE, Bilbao, Spain Centre for Pathology, Imperial College London, St Mary’s Hospital, London, W2 1NY, UK German Cancer Research Center, Heidelberg...
متن کاملDownregulation of Dickkopf-3 disrupts prostate acinar morphogenesis through TGF-β/Smad signalling.
Loss of tissue organization is a hallmark of the early stages of cancer, and there is considerable interest in proteins that maintain normal tissue architecture. Prostate epithelial cells cultured in Matrigel form three-dimensional acini that mimic aspects of prostate gland development. The organization of these structures requires the tumor suppressor Dickkopf-3 (Dkk-3), a divergent member of ...
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15 صفحه اولFate and Function Dickkopf-3 Acts as a Modulator of B Cell
The mechanisms responsible for the generation of a mature B1 and B2 cell compartment are still poorly understood. In this study, we demonstrated that absence of Dickkopf-3 (DKK3) led to changes in the composition of the B cell compartment, which were due to an altered development and maintenance program of B cells. Development of B2 cells was impaired at the pre-and immature B cell stage, resul...
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ژورنال
عنوان ژورنال: BioArchitecture
سال: 2013
ISSN: 1949-0992,1949-100X
DOI: 10.4161/bioa.25243